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In humans, at doses recommended for treatment of patients with chronic obstructive pulmonary disease (50 – 100 mg / day), ARMANOR® improves gas exchange function through stimulation of peripheral chemoreceptors aortic and carotid sinus:
In applying the drug at the indicated doses observed effects are independent of any changes in the ventilation in general, which is indicated by:
The research on the mechanism of action of the drug ARMANOR, it was shown that the observed improvement in gas exchange function are combined with the corresponding improvement in ventilation-perfusion relationships.
These effects combined with improved alveolar ventilation that was observed during long-term use of the drug, and contributed to the overall improvement of halotestin cycle gas exchange function.
When use of the drug in doses exceeding 100 mg (oral, single dose), probably a transient and moderate increase in general ventilation, which can cause poor tolerability.
Pharmacokinetics
Almitrin rapidly absorbed after oral administration, the peak concentration achieved after 3 hours the plasma. Studies that examine the distribution of the drug was shown to be metabolized primarily by the liver. Almitrin and its metabolites are excreted mainly in the bile turinabol for sale. Thus, elimination of the drug takes place mainly in the faeces to a lesser extent – in the urine as inactive metabolites. After a single dose half-life is 40 – 80 hours. When he re-admission is reduced to 30 hours. Almitrin very well associated with blood proteins (over 99%).
Indications
ARMANOR indicated for respiratory failure accompanied by hypoxia, developed on the background of chronic obstructive bronchitis.
The drug is released only by prescription.
Proitivopokazaniya
Special precautions :
Peripheral neuropathy
ARMANOR should not be taken with other drugs halotestin cycle containing almitrin (PREMODAL).
The recommended dose and dosing schedule should be agreed in the following cases:
ARMANOR® administered in a dose of 50 -100 mg (1 – 2 tablets per day) twice a day. The drug is taken during the main meal. After an initial period of treatment for 3 months starting dose recommended maintenance treatment, which is carried out as follows:. Two months of treatment followed by a break in taking the drug for one month
Before the drug may need dose adjustment depending on the patient’s weight, severity of disorder gas exchange function and the presence of side effects:
In appointing the drug at a dose of more than 2 tablets a day, you need a professional opinion.
The lack of renal elimination pathway of the drug means that in patients with renal insufficiency dose adjustment ARMANORA® not required.
Application ARMANORA® compatible with concomitant oxygen therapy.
Side effect
Side effects, celebrated in rare cases:
Overdose
There were no cases of drug overdose.
However, in cases of significant accidental overdose hypocapnia signs can appear with the development of respiratory alkalosis.
Treatment: symptomatic treatment available under the control of disorders of lung function, heart and blood gases.
release Form
30 tablets each containing 50.0 mg almitrina halotestin cyclea in blister packs
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